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Leiter:
Prof. Dr. Bodo Grimbacher
Mitarbeiter:
Teresa Sprang
Dr. Manfred Fliegauf
Dr. Stefanie Frey-Jakobs
Dr. Michele Proietti
Noriko Mitsuiki
Dr. Alla Bulashevska
Sabine El-Helou
Dr. Jan Pruszak
Ina Caroline Rump
Linlin Yang
Zoya Eskandarian
Nadezhda Camacho
Neftali Ramirez
Katrin Hübscher
Pavla Mrovecova
Jessica Rojas
Mary Buchta
Hanna Haberstroh
Nadine Glaser
Niko Langer
Máté Krausz
Nils Klammer
David Egg
Carla Arteaga
Alexa Gagas
Svenja Abel
Cornelia van Schewick
Felicitas Felber
Johanna Neubauer

"Experimental Immunodeficiency"

 

The research group „Experimental Immunodeficiency“ focuses on the Genetics and Molecular Pathophysiology of Primary Immunodeficiencies.

 

Primary immunodeficiencies due to monogenetic defects in humans are an experiment of nature. Their investigation enables physicians and researchers to dissect the immune system and evaluate the respective components in human immunology. The identification of new disease genes leads to improved diagnosis and disease management, and ultimately, by illuminating the pathophysiology, to the development of new therapeutic strategies. Currently my group follows the following topics:

 

 

    1. Genetic causes of common variable immunodeficiency (CVID)
    2. The genetic cause of the hyper-IgE recurrent infection syndrome (HIES)
    3. The genetic cause of chronic mucocutaneous candidiasis (CMC)
    4. The molecular pathology of chronic inflammatory bowel disease
    5. The molecular pathology of LRBA deficiency
    6. Determination of the genetics of primary immunodeficiency by next generation sequencing
    7. Analysis of whole exome and whole genome sequencing data
    8. Clinical Research Registries

Publikationen

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