Our team utilizes transgenic mice and other model organisms to understand complex signaling programs that regulate the development, the maintenance and the disease progression of the kidney glomerulus. The molecular insights are used to identify novel targets to treat human glomerular diseases, which are the most common cause of end stage renal failure.
We initiated a Glomerular Research Programm for the analysis of signalling networks regulating glomerular diseases. This platform includes various transgenic mouse models and invertebrate models to identify different aspects of glomerular diseases. We truely believe in the inestimably value of scientific cooperation and many of our projects involve close local, national and international collaborations.
Glomerular kidney diseases are of major public health importance not only because of their high prevalence, but also because they are a major independent risk factor for cardiovascular morbidity and mortality. Despite the crucial importance of the kidney both as a target and as determinant of human disease, knowledge of the molecular networks underlying glomerular development, regeneration and diseases is very limited. Our studies aim to elucidate molecular programs that will help to formulate therapeutic interventions that delay the onset and progression of glomerular diseases.
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