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Dr. Alexis Hofherr
Dr. Tilman Busch
Simone Diederichsen
Julia Merkel
Susanne Helmstädter
Lea Osterried
Elisabeth Michel
Frieder LInden
Oliver Wegehaupt
Lukas Westermann
Jingting Luan
Andreas Nold

Our laboratory is interested in the molecular design and functional specificity of signal transduction pathways. One of the fundamental challenges of modern biology is to understand how cells generate, integrate, and respond to dynamic cues in order to exert their roles within multicellular organisms.
We are using an interdisciplinary approach to investigate signal transduction at all levels of complexity: from single molecules to whole organisms. We study signaling in the context of physiological and pathological functions of proteins involved in monogenic and complex genetic diseases.
Our research focuses on three main topics:

1. TRP channels and calcium signaling
2. Autosomal Dominant Polycystic Kidney Disease
3. Gout 


Join our Laboratory

One of the major goals of our lab is to train a new generation of scientists interested in understanding signal transduction, membrane proteins and functional genetics of disease. We are interested in recruiting smart, ambitious and friendly students and postdocs. The community of scientist transcends national borders and cultures. We strive to recruit a diverse group of people because we believe that this fosters an environment of creativity, which stimulates exciting ideas and promotes good science. If you are interested in joining our group read on.

Medical thesis (Doktorarbeit), Diploma in Molecular Medicine/Biology

Our department is not only dedicated to research, but is equally committed to teaching and training.        We view the medical doctoral thesis and the diploma thesis for students of Molecular Medicine or Biology as a great opportunity, to convey our excitement for research to students.
To provide every student with a concise and efficient training experience, we offer a biannual workshop that combines an overview in molecular biology with “hands-on” training in the lab. Over a two-week training period, all students starting with their doctoral or diploma thesis in our laboratory will learn the basic standard techniques, and obtain a theoretical framework to understand the ongoing research in the laboratory. PhD students of the Spemann Graduate School of Biology and Medicine will participate in this workshop and contribute to lively discussions.
The typical medical thesis requires around eight months of experimental work at the bench.                      The work will be closely supervised by an experienced postdoc or group leader. To ensure that the work can be successfully completed, we assign clearly defined projects. All methods are established in the lab. Students often voice their interest to continue with some part-time research after the completion of their thesis. We therefore hire interested students as “Studentische Hilfskräfte (Hiwis)”, and appreciate their contribution to the ongoing research projects. Several students have performed guest rotations in other laboratories in Germany or abroad (Harvard, Johns Hopkins University, ...). These activities are supported by either stipends or departmental funds, and provide additional learning experience both on a personal and scientific level.


If you are looking for a postdoctoral position please send an e-mail to Michael Köttgen with a cover letter describing what you have worked on, your research interests and what your career goals are. Please enclose your CV and the names, e-mails and phone numbers of two to three references. To be considered, you will need at least one publication in an international journal. It is beneficial but not required if you have a reasonable chance of getting a fellowship to support your stay in our lab in Freiburg.

Physician scientists (M.D./Ph.D.)

Highly motivated and qualified medical doctors (M.D.) may pursue an academic career by combining scientific work in our lab with clinical training in the Department of Nephrology. You will work in the lab and participate in a well-organized clinical curriculum to guarantee the best scientific and clinical training possible. Interested individuals may participate in a newly established M.D.-Ph.D. program (Spemann Graduate School of Biology and Medicine). After a six-year training period, the candidate should be board-certified in both Internal Medicine and Nephrology, and either continue in the department as a junior faculty member, pursuing independent research, or seek additional qualifications in collaborating laboratories or hospitals, in Germany or abroad. The typical applicant has successfully finished a doctoral thesis in a basic science laboratory, and wants to combine state of the art research in basic sciences with excellent clinical training. Applications should be directed to Michael Köttgen .




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